FGFR1 and cardiovascular disorder: Both FGFR1 and FGFR2 have been reported to be critical embryonic developmental factors, crucial for survival and injury response.18 Defects in the FGF/FGFR signaling pathway have been closely correlated with cardiovascular diseases due to the modulation of angiogenic and neovascularization responses.19 Furthermore, a tumor cancer manifestation in the CNS can be cataloged as an injury, meaning a vascular response occurs in many of the cases and an impaired FGF/FGFR signaling pathway such as a point mutation on the gene will affect the maintenance of neovascular vessels.