FGFR1 and intracranial hemorrhage: Additionally, a statistical significance was established between intracranial hemorrhage and the PTPN11 gene, which often co-occurs with FGFR1, suggesting a cooperative role of these mutations.16 Unlike Ishi et al., (2020), who found a statistical significance between hemorrhagic events and the diencephalic region, we did not see any correlations between intracranial hemorrhage and the location of the tumor.