UFSP2 and Alzheimer disease: In multivariable analysis adjusting for age and sex, compared to controls, there were significantly (P<0.025 considered significant) higher levels of soluble UFM1 in the temporal cortex (P=0.017), higher levels of insoluble UFSP2 in the frontal cortex (P=0.017), as well as higher levels of both soluble (P=0.002) and insoluble UFM1 (P<0.001) in the frontal cortex of AD patients (Table 1).