IFNA1 and cancer: Cancer-associated pathways influenced by SIS ECM in CT26 spheroids were driven by an upregulation in 2’−5’ oligoadenylate synthetases 2 and 3 (Oas2, Oas3) (Supplementary Fig. 6d) also associate with immune regulation, which are enzymes activated by IFN signaling cascades and has been shown to establish an immunosuppressive microenvironment46.