Accordingly, in PAECs from IPAH patients (Figure 6C) and in BMPR2-silenced PAECs (Figure 6D), DLL4 not only induced PPARG transcription, but also increased mRNA expression of several PPARγ target genes (FABP4, CYP1A1, PGK1 and HK1). Here, CYP1A1 is linked to idiopathic pulmonary arterial hypertension.