Given the strong induction of proteins that are regulatory or can act in regulatory manners (IL-10, IL-29, IL-6, IL-1Ra), the negative correlation of severe trauma with the ability to fight off infections like pneumonia, and post-acute sequelae of both infections and trauma, these data support future studies on the networked role of responses to pathogens and traumatic injury. This evidence concerns the gene IFNL1 and infection.