While studies have shown that mutations in the dynein motor machinery are often sufficient to cause motor neuron diseases (i.e. Huntington Disease, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease, among others (15, 23, 26, 67, 68)), until this study, the role of LIC1 in endothelial cell biology and angiogenesis had remained unknown. Here, DYNC1LI1 is linked to early-onset autosomal dominant Alzheimer disease.