While studies have shown that mutations in the dynein motor machinery are often sufficient to cause motor neuron diseases (i.e. Huntington Disease, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease, among others (15, 23, 26, 67, 68)), until this study, the role of LIC1 in endothelial cell biology and angiogenesis had remained unknown. The gene discussed is DYNC1LI1; the disease is amyotrophic lateral sclerosis.