FGFR2 and neoplasm: Amplification and overexpression of the FGFR2b splice variant have been linked to the deletion of a proximal coding exon causing persistent activation of the FGFR2 receptor, promoting oncogenesis.1,6-9 Studies evaluating the impact of FGFR2 amplification in gastric adenocarcinoma showed an association with lymph node metastases (Odd’s ratio [OR] 3.93, P < .00001), poor differentiation (OR 2.36, P < .04) and worse prognosis/survival (HR 2.09, P < .00001); these did not, however, demonstrate an increased rate of tumor invasion.9,10