The abundance of Acetivibrio as an SCFA-producerwas reported to activate the AMPK-SIRT1 pathway, contributing to theprotection of dietary tryptophan against intestinal inflammation response.38 DFER supplementation could effectively preservethe growth of Acetivibrio, accompanied by significantlyhigher fecal acetic acid, which might assist in the ameliorative effecton obesity. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.