These indeterminate patients (with elevated ALT and HBV DNA levels between 2 × 103 IU/mL and 2 × 104 IU/mL) should be treated with antiviral therapy, especially if they are older than 40 years, or have liver cirrhosis, a family history of HCC, previous treatment history, extrahepatic manifestations, or a long duration of HBV infection [2, 4]. This evidence concerns the gene GPT and hepatocellular carcinoma.