According to adjusted model, significant negative correlations were found between PHDI and PDP with prostate cancer (PHDI: OR = 0.31; 95% CI; 0.11–0.85; P = 0.023 – PDP: OR = 0.34; 95% CI; 0.15–0.75; P = 0.008). This evidence concerns the gene PDP1 and Familial prostate cancer.