According to crude model, a significant relationship was observed between prostate cancer risk and NHDI (OR = 2.77; 95% CI (1.32–5.85); P = 0.007) also an inverse relation with PDP (OR = 0.34; 95% CI (0.16–0.72); P = 0.005). This evidence concerns the gene PDP1 and Familial prostate cancer.