HLF and neoplasm: In addition, in non-small cell lung cancer, miR-296-3p acts as a tumor suppressor and inhibits tumor cell migration and invasion by targeting apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) expression [59], and APEX1 can further promote the transcriptional activation of HIF1 or hypoxia-inducible factor-like factor (HLF) as a hypoxia-related gene [60].