Moreover, METTL1 upregulates the expression of chemokines CXCL5 and CXCL8 in an m7A-dependent manner, leading to MDSCs accumulation and immunosuppression in HCC and intrahepatic cholangiocarcinoma (ICC) [238, 239] (Fig. 4). This evidence concerns the gene METTL1 and hepatocellular carcinoma.