Given that SAL induces the expression of BHLHE40 and that the BHLHE40 KD reduces the senescence level in PCa cell lines, transcriptome data were analyzed and classified into subsets of genes dependent on their up- or downregulation to identify specific AR-BHLHE40 transcriptome landscapes and specific regulated pathways by these two transcription factors. Here, BHLHE40 is linked to posterior cortical atrophy.