Thus, these data confirm the induction of AKT and p70S6K phosphorylation by BHLHE40 KD suggesting that the BHLHE40 mediated cellular senescence especially under SAL treatment is associated with a pathway that leads to suppression of AKT and p70S6K phosphorylation and thus provides a novel AKT-alternative pathway to control cellular senescence in PCa. The gene discussed is AKT1; the disease is posterior cortical atrophy.