The functional role of BHLHE40 in SAL-induced cellular senescence in PCa by modulating BHLHE40 expression levels through knockdown (KD) and overexpression (OE) experiments in both CSPC LNCaP and the CRPC C4-2 cell lines were analyzed suggesting that BHLHE40 is part of SAL-induced cell senescence program. This evidence concerns the gene BHLHE40 and posterior cortical atrophy.