BHLHE40 encoding DEC1 mediates cellular senescence by its direct target gene CCNG2, that encodes the atypical and tumor suppressive Cyclin G2, as a novel tumor suppressive axis encompassing androgen receptor-BHLHE40-Cyclin G2 in order to mediate cellular senescence in PCa cells (Fig. 7). The gene discussed is BHLHE40; the disease is neoplasm.