In HNSCC, 132 different lncRNAs were identified under different HPV-infected states of HNSCC, among which HOTAIR, PROM1, CCAT1 and MUC19 were negatively correlated to myeloid-derived suppressor cell recruitment in HPV-associated HNSCC [21]. The gene discussed is HOTAIR; the disease is head and neck squamous cell carcinoma.