Due to the combinated anti-tumor performances of ED-M@CS/MC involved both the chemotherapy and the immunological effect based on improving anti-tumoral immune infiltration and immunogenic DAMPs, C57BL/6 mice and KrasLSL−G12D/+(KI/+), Trp53LSL − R172H/+(KI/+), and Pdx1-Cre (TG/+) (KPC) mice obtained through KrasLSL−G12D/+(KI/+), Trp53LSL − R172H/+(KI/+) (KP) mice and Pdx1-Cre (TG/+) (PC) mice were used to investigate the synergistic combination effect of chemotherapy and anti-tumor immunity treatment. Here, PDX1 is linked to neoplasm.