ERBB2 and neoplasm: These data indicate that the HER2-silenced cells have a lower content of aromatic amino acids than the SCR-SKBR3 counterpart, confirming that this selected group of amino acids is heightened in tumour-derived cell lines as a marker of a robust protein synthesis and of the aggressive HER2 + phenotype due to amplification of the HER2 receptor that conveys growth factors stimuli.