ELFN2 and colorectal carcinoma: To understand how the HLM score predicts the prognosis of patients with CRC, we performed a single gene analysis of six characterized genes in C1 and C3 subtypes, and the Kaplan–Meier curve indicated that the overexpression of TRIB2 or ELFN2 predicted poorer OS in patients with CRC, with HRs of 2.39 (95% CI 1.30–4.40, p < 0.01, Fig. 10D) and 1.88 (95% CI 1.05–3.38, p = 0.03, Fig. 10G), respectively.