Ravi et al. applied an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples and identified that a subset of interleukin-10-releasing HMOX1+ myeloid cells, spatially localized to mesenchymal-like tumor regions, drive T-cell exhaustion and thus contribute to the immunosuppressive TME [136]. The gene discussed is IL10; the disease is neoplasm.