Depending on the specific environment, DN cells can exhibits different functions: as T helper (TH) cells, DN cells can secrete cytokines like interleukin(IL)-17 and interferon-γ (IFN-γ) that may conduce to their protective effects against non-small-cell lung cancer (NSCLC) [14] and acute myeloid leukemia (AML) [64]; as cytotoxic T lymphocytes, they also possesses anti-tumor functions in leukemia [65] and lung cancer [15]. This evidence concerns the gene IFNG and neoplasm.