The overexpression in LCa patients of serum-derived exosomal epitopes correlating with cancer presence, compared to healthy controls (CD1c, CD2, CD3, CD4, CD14, CD11c, CD20, CD44, CD56, CD105, CD146, and CD209), alongside with specific ones linked to nodal involvement (CD24, CD31, CD40), suggests a multifaceted role for these markers in LCa pathology. Here, CD40 is linked to Leber congenital amaurosis.