There were no significant differences in gender, age, ADL scores, BMI, duration from admission to surgery, Surgical duration and Blood loss between the Control group and the THSWD group (Table 2).The results showed that there was no significant difference in the expression of these inflammatory factors (COX-2 IL-1β, IL-6 and TNF-α) between the two groups on the day of delirium onset (before treatment). This evidence concerns the gene PTGS2 and delirium.