CALR and neoplasm: This phosphorylation event leads to the formation of a pore complex of mixed lineage kinase domain-like protein (MLKL) on the plasma membrane that increases the immunogenicity of tumor cells and results in the secretion of damage-associated molecular patterns (DAMPs) [17], which include surface-exposed calreticulin (CRT), secreted adenosine triphosphate (ATP), and high mobility group protein B1 (HMGB1) [18].