SYP and Alzheimer disease: The diagnostic efficacy of synaptophysin by ROC analysis was observed as follows for AMC vs MCI (AUC = 0.8507, p < 0.0001, Sn = 80%, Sp = 86.67%) (Fig. 3V), AMC vs AD (AUC = 0.9738, p < 0.0001, Sn = 88.57%, Sp = 96.67%) compared to AMC (Fig. 3W); MCI vs AD (AUC = 0.8291, p < 0.0001, Sn = 85.71%, and Sp = 68%) (Fig. 3X).