The diagnostic efficacy of IL-1β by ROC analysis was observed for AMC vs MCI (AUC = 0.9520, p < 0.0001, Sn = 96%, Sp = 86.67%) (Fig. 3J), AMC vs AD (AUC = 0.9857, p < 0.0001, Sn = 94.29%, Sp = 90%) compared to AMC (Fig. 3K), MCI vs AD (AUC = 0.9114, p < 0.0001, Sn = 85.71%, Sp = 92%) (Fig. 3L). Here, IL1B is linked to Alzheimer disease.