Among target genes of miR-146b-3p, HMGCR, GSE1, and ELF4 were identified to be dysregulated in RA from a GEO dataset, and only HMGCR was negatively regulated by miR-146b-3p in TNF-α-stimulated FLSs. The gene discussed is HMGCR; the disease is rheumatoid arthritis.