This dual action was confirmed recently in a colorectal cancer model where DAB2IP reconstitution inhibited tumor formation and progression in vivo; in this context, both the RasGAP domain and the period-like domain are necessary to suppress tumor development, in particular by preventing NF-κB signaling and the recruitment of pro-tumorigenic macrophages [20]. This evidence concerns the gene NFKB1 and neoplasm.