TARDBP and neuroblastoma: Taken together, using murine neuroblastoma Neuro2a cells and C. elegans, we demonstrate the role of misfolding of tRRM2 and GRR as IDR of TDP-43 CTF during their condensation containing amyloidogenic aggregation by analyzing the efficiency of cytoplasmic condensation, molecular fluidity in condensates, and oligomeric states in lysate, of various TDP-43 CTFs.