GSEA of the most differentially expressed genes (log2-transformed fold change > 5, adjusted P (Padj) < 0.01) from the mouse tumors (Lyz1 tumor signature, n = 27 genes; Lgr5 tumor signature, n = 40 genes) revealed a significant association between the Lyz tumor signature and IBD-CRC (NES = 1.67, Padj = 6.2 × 10−3), whereas the Lgr5T profile was significantly associated with sCRC (NES = −1.62, Padj = 0.013) (Fig. 3f, Extended Data Fig. 7a–c and Supplementary Table 3). Here, LGR5 is linked to inflammatory bowel disease.