Evaluation of the hallmarks from the molecular signature database39 revealed gene sets common to PC-derived tumors and IBD-related CRCs (interferon alpha/interferon gamma, inflammatory response, IL-6/IL-2 signaling, KRAS, complement, allograft rejection), and to Lgr5-derived tumors and sCRCs (MYC targets, G2M checkpoint, E2F targets and WNT β-catenin signaling) (Fig. 3g and Extended Data Fig. 7d). Here, LGR5 is linked to inflammatory bowel disease.