Of note, although cells expressing the PC marker lysozyme (LYZ1) were notable in Lgr5-derived tumors (Lgr5/Apc: 30.0% ± 18.5% positive tumor cells), they were almost absent in adenomas that originated from PCs (Lyz1/Apc: 0.48% ± 1.16%) (Fig. 1g,h). This evidence concerns the gene APC and adenoma.