LGR5 and colorectal carcinoma: We then compared the differentially expressed genes from PC-derived versus Lgr5-derived mouse tumors and human IBD-CRC versus sCRC (Paneth/IBD-CRC, n = 49 genes; Lgr5/sCRC, n = 27 genes) and visualized their expression across different cell types based on a large scRNA-seq CRC study40 (Fig. 3h).