The opposite was observed for DCLK1 (doublecortin-like kinase 1), a Tuft19 and tumor stem cell marker20,21, that was more frequently detected among PC-derived adenomas (Lyz1/Apc: 54.1% ± 10.5%) when compared with Lgr5-derived tumors (Lgr5/Apc: 15.6% ± 15.7%) (Fig. 1i,j). This evidence concerns the gene DCLK1 and adenoma.