While it was known that IFN-γ via STAT1 could increase HLA-E levels, we here indisputably prove that CREB1 and STAT1 both contribute to HLA-E expression in myeloma, with CREB1 binding to HLA-E promoter and CREB1 inhibitors decreasing HLA-E expression in cell lines and patient samples. The gene discussed is CREB1; the disease is plasma cell myeloma.