The major clinical trials in this area have assessed whole body hypothermia,4,6,9,19 selective head cooling,5 depth and duration of TH20 and erythropoietin.10 Regardless of the terminology used in these trials, which varied between encephalopathy, HIE and PA, they attempted to identify a cohort of infants with encephalopathy secondary to a purely hypoxic aetiology. Here, EPO is linked to Encephalopathy.