Overall, the Wnt signalling pathway, melanogenesis, and other cancer-associated signalling pathways may be associated with the development of AML due to differences in their expression of pleomorphic adenoma gene 1 (PLAG1), frizzled class receptor 3 (FZD3), annexin A2 (ANXA2), has-microRNA-155, and has-microRNa-192, may play crucial roles in the oncogenesis of AML. The gene discussed is ANXA2; the disease is cancer.