The KEGG enrichment analysis of RNA sequencing results on TNBC-specific CTLs indicated that PD-L1 expression and PD-1 checkpoint pathway in cancer was co-inhibited by IL23 and PD-1 mAb through downregulating PIK3R1, which encodes the regulatory subunit p85α of class IA PI3Ks. This evidence concerns the gene PIK3R1 and cancer.