However, in Asic3−/− mice, the chemical denervation of TRPV1+ nociceptors failed to further alleviate splenomegaly in the psoriasis model (Supplementary Fig. 6b), arguing for the essential role of ASIC3 in the TRPV1+ nociceptor-mediated regulation. The gene discussed is TRPV1; the disease is Splenomegaly.