The conditional rescue of ASIC3 in NaV1.8Cre mice led to more severe epidermal thickening and Ki67 cell proliferation (Supplementary Fig. 4e–g), as well as higher production of psoriasis-related cytokines, IL-17, IL-22, and IL-23, compared to the ASIC3 knockdown mice (Supplementary Fig. 4h). The gene discussed is ASIC3; the disease is psoriasis.