Mechanistically LAPTM4B can regulate cancer progression via several pathways: LAPTM4B promotes integrin beta1 recycling and regulate cytoskeleton organization, thus enhances cell migration [22, 23]; It regulates drug resistance via the PI3K-AKT pathway [24], stimulates tumor growth via activating mTORC1 signaling [25], and regulates cell growth and autophagy though prolonging EGFR signaling [26, 27]. This evidence concerns the gene LAPTM4B and neoplasm.