Previous studies indicate LAPTM4B inhibits apoptosis [18, 42] and promotes autophagy [20], our experiments from A549 and H1299 cells reported upregulated apoptotic cell rate (Supplementary Fig. S5C) and reduced LC3-II level (Supplementary Fig. S5D) in LAPTM4B knockout cells, suggesting LAPTM4B still regulates apoptosis and autophagy in NSCLC. The gene discussed is LAPTM4B; the disease is non-small cell lung carcinoma.