Likewise, a significantly higher frequency and mean fluorescence intensity (MFI) of Fgl2 cytokine expression was observed within CD44hi CD8+ T cells compared to CD44lo CD8+ T cells during ex vivo peptide stimulation of cells isolated from the spleen (p < 0.01) and tumor (p < 0.05) of B16-OVA challenged mice (Supplementary Fig. 1e–g). Here, CD8A is linked to neoplasm.