GPER1 and Zygomycosis: Our analysis also predicted the activation of signaling pathways that have not been tied directly to mucormycosis including neural precursor-cell-expressed developmentally down-regulated protein 9 (NEDD9), G-protein coupled estrogen receptor 1 (GPER1), and hypoxia-inducible factor-1α (HIF1α)29–33 (Fig. 2A).