The most salient findings of our study are (1) R. delemar infection induces HIF1α activation in airway epithelial cells; (2) HIF1α activation promotes fungal invasion into host cells; (3) HIF1α activation promotes a transcriptional innate immune response during R. delemar infection; and (4) inhibition of HIF1α increases survival in an in vivo murine model of mucormycosis. This evidence concerns the gene HIF1A and Zygomycosis.