Given that SCAF1 is a close homolog of SCAF4/8 and also part of the RNA polymerase II complex, it is interesting to speculate whether the shorter ~30 kDa USP15 isoform with concomitant reduction of the long USP15 isoform observed in Scaf1 knock-out pancreatic cancer cells might also be the result of premature polyadenylation. Here, SCAF1 is linked to familial pancreatic carcinoma.