USP15 and pancreatic ductal adenocarcinoma: Interestingly, PARP inhibition induced decreased hedgehog signaling in USP15 and SCAF1 knock-out cells and given that preclinical studies indicated that hedgehog pathway inhibition reduces growth and metastasis of pancreatic ductal adenocarcinoma cells67–69, it will be interesting to explore whether PARP inhibition would synergize with hedgehog inhibition in USP15 or SCAF1 loss-of-function setting.