The other cells, where SMAD3 showed significant difference between AD and controls, were six excitatory neuron clusters (cluster1: β = −0.045, q = 0.00028; cluster2: β = 0.057, q = 0.00084; cluster3: β = 0.034, q = 2.40e-06; cluster4: β = 0.063, q = 0.01117; cluster17: β = 0.071, q = 0.00186; cluster24: β = 0.019, q = 0.00101), and the OPC cluster (Cluster9: β = −0.090, q = 0.01320). This evidence concerns the gene SMAD3 and Alzheimer disease.