MAPK14 and cancer: The particular example used is the Mitogen-activated protein kinase 14 (p38-α) protein (PDB code 3HEC), a well-known protein kinase enzyme, in complex with the FDA-approved Imatinib (PDB Ligand code STI, DrugBank [34] Ligand Code DB00619), a small molecule kinase inhibitor used to treat certain types of cancer.