By contrast, studies with the SfA-derived pancyclophilin inhibitor GS-642362, which targets PPIA, PPIB, and PPIF, in the unilateral ureteric obstruction (UUO) mouse model showed inhibition of renal fibrosis by preventing tubular epithelial cell death and neutrophil infiltration (55). This evidence concerns the gene PPIA and Ureteral obstruction.