PPIB-deficient mice are viable and partially protected from inflammation in the UUO model at day 7, although fibrosis was not assessed at later time points (56), while efforts with PPIA-deficient mice show reduced inflammation in the bilateral renal ischemia/reperfusion injury (IRI) model but are not protected from renal fibrosis in the UUO model, suggesting that PPIA regulates inflammation but not fibrosis (57). This evidence concerns the gene PPIB and ischemia.