PPIB-deficient mice are viable and partially protected from inflammation in the UUO model at day 7, although fibrosis was not assessed at later time points (56), while efforts with PPIA-deficient mice show reduced inflammation in the bilateral renal ischemia/reperfusion injury (IRI) model but are not protected from renal fibrosis in the UUO model, suggesting that PPIA regulates inflammation but not fibrosis (57). The gene discussed is PPIA; the disease is renal fibrosis.