By contrast, studies with the SfA-derived pancyclophilin inhibitor GS-642362, which targets PPIA, PPIB, and PPIF, in the unilateral ureteric obstruction (UUO) mouse model showed inhibition of renal fibrosis by preventing tubular epithelial cell death and neutrophil infiltration (55). The gene discussed is PPIB; the disease is renal fibrosis.