Finally, immune checkpoint blockade with anti–PD-1 Ab, adoptive PD-1–deficient T cell transfers, and genetic deletion of PD-1 reinstated or exacerbated Aldo-salt–induced or HFD- and Ang II–induced aortopathies, including elastin degradation, vascular inflammation, TAA, and AAA in intact and orchiectomized mice (Figures 10−12). Here, ELN is linked to triple-A syndrome.