Additionally, adoptive PD-1–deficient T cell transfer, relative to adoptive WT T cell transfer, led to a significant increase in the external diameters of the RootAo, AscAo, and SupAo 4 weeks after Aldo-salt administration (Figure 11D), along with a 60% incidence of TAAs, 10% of AAAs, and 40% of aortic ruptures (Figure 11E). The gene discussed is PDCD1; the disease is achalasia-alacrima syndrome.