CXCL8 and neoplasm: Moreover, CXCL8 can act in a paracrine manner to change the composition of immune infiltration in TME, by recruiting tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and neutrophils to the TME, resulting in dampening the anti-tumour immune response of cytotoxic immune cells [35, 36].