CXCL8 and cancer: TCM is composed of both solid (cell features like cancerous, normal and immune infiltrate) and soluble mediators (chemokines, cytokines and growth factors), among which Interleukin-8 (named also CXCL8 or IL-8), is the chemokine most widely investigated not only in TC but also in several types of human cancers [11, 12].