In the process, transforming growth factor-β (TGF-β), as a pivotal cytokine in the TME, controls various cells’ fates and influences numerous metabolic pathways, including inhibiting immune cells to infiltrate the tumors, suppressing the activation of anti-tumor immune cells, facilitating more immunosuppressive cells, enhancing glucose and glutamine metabolism, dysregulating bone metabolism and so on. This evidence concerns the gene TGFB1 and neoplasm.