ATG12 and intestinal obstruction: Consistently, the groups with severe intestinal obstruction in the context of trpQ78 (that is, Atg5, Atg7 RNAi) displayed more severe apoptosis, while the Atg1 and Atg12 RNAi groups, which had mitigated intestinal obstruction, had reduced apoptosis levels (Fig. 5e, f).