Twenty-four hours after cardiac I/R injury, we observed a significant decrease in the area of myocardial infarction (Fig. 4b, c), less TUNEL positive in mouse heart tissue (Fig. 4d, e), reduced levels of plasma CK (Fig. 4f) and LDH (Fig. 4g), as well as lower transcription levels of Tnfa (Fig. 4h) and Il1b (Fig. 4i) in cardiac tissue detected by qPCR compared to the wild-type group in mice treated with mDR5-Fc compared to the PBS group. This evidence concerns the gene IL1B and myocardial infarction.