B2M and relapsing-remitting multiple sclerosis: To investigate the potential of PBMC from MS patients to induce CNS-directed immunopathology in humanized mice, we engrafted B2m-NOD/scid-IL2Rγnull (B2m-NOG) mice with PBMC from human donors based on HLA-DRB1 genotype, relapsing remitting MS (RRMS) diagnosis and therapy, and monitored CNS inflammation that developed spontaneously or after immunization for EAE with myelin antigens.