A peptide cocktail containing myelin epitopes previously associated with MS, specifically hMOG35-55, MOG1–20 and MBP83-99 (Pette et al., 1990; Ota et al., 1990; Kerlero de Rosbo et al., 1993; Cao et al., 2015), plus mMOG35-55, was chosen for immunization in groups of 12- to 14-week-old humanized B2m-NOG mice on dpt 14. Here, RANGRF is linked to myeloid sarcoma.