Given the relevance of congenital HCMV infections and the fact that trophoblasts do not express HLA-A and -B, but HLA-C, -G, and -E (Hackmon et al., 2017), this prompts the question as to whether US10 makes an important pathogenic contribution to placental infection, subsequent transmission to the fetus. This evidence concerns the gene HLA-A and cytomegalovirus infection.