Palada et al.53 and Brisby et al.11 reported elevated IL8 in the CSF of patients with LDH, which we could replicate, while we could not replicate findings of elevated CSF IL1b, IL10, and TNF in thoracic disk herniation.4 Krock et al.42 deemed CSF IL8 as important in DDD, while fractalkine was undetectable. The gene discussed is CXCL8; the disease is Dowling-Degos disease 1.