To further confirm that METTL3 regulates thyroid cancer differentiation through the SETMAR‐SMARCA2‐TTF axis, we knocked down SETMAR in METTL3 overexpressed ATC cells and found that the up‐regulated SMARCA2 and thyroid differentiation markers caused by METTL3 overexpression can be rescued by SETMAR silencing (Figure S9E, Supporting Information). The gene discussed is RHOH; the disease is thyroid cancer.