SETMAR, also known as METnase, is a fusion protein between a SET domain protein methylase and the transposase Hsmar1.[15] Previous studies have shown that SETMAR plays an important role in different cellular processes, such as nonhomologous end joining (NHEJ), the integration of transfected plasmids and lentiviruses, chromosome decatenation, and the regulation of gene expression.[14] However, how SETMAR functions in thyroid cancer has not been determined. This evidence concerns the gene SETMAR and thyroid cancer.