Notably, SMARCA4 and SMARCA2 are two important mutually exclusive catalytic subunits in the SWI/SNF complex, and they have a high degree of homology.[42] In addition, the paralog dependency model has been employed to elucidate the SWI/SNF complex, where SMARCA2 and SMARCA4 can compensate for the absence of one another.[24] As a result, understanding how SMARCA4 functions in thyroid cancer may be of significant scientific benefit. The gene discussed is SMARCA4; the disease is thyroid cancer.