To date, PD‐1 blockade plus chemotherapy has become the standard first‐line setting for many solid tumors including advanced NSCLC, esophageal, gastric, nasopharyngeal cancer, etc. Given the addition of chemotherapy would increase tumor cell death associated antigen release and elimination of some immunosuppressive cells, such as myeloid‐derived suppressor cell (MDSCs), regulatory T cells (Tregs) and so on,25, 26, 27 whether sex had impact on the efficacy of PD‐1 blockade plus chemotherapy in untreated advanced NSCLC remained undetermined. The gene discussed is PDCD1; the disease is neoplasm.