Additionally, leucine-rich repeat kinase 2 (LRRK2), a causative protein in PD, is essential in regulating autophagosome and lysosomal trafficking, particularly in partnership with JIP4 (Bonet-Ponce et al., 2020; Kluss et al., 2022a; Kluss et al., 2022b). Here, LRRK2 is linked to Parkinson disease.